MURPHY - Karen M. (nee Knight) Of South Buffalo, NY, August 22, 2022. Beloved wife of John J. Murphy; dearest mother of Shawn P. Murphy, Christina (Ian) Gallagher, Laurie A. (Craig) Clark and Michael J. (Christina) Murphy; grandmother of Emmett, Lily, Patrick, Mackenzie, Colin, Grace and Grant; daughter of the late Gerald J. and Dorothy M. (Codd) Knight; sister of Robert (Sandy) Knight, Joann (Thomas) Jindra and Timothy (Cindy) Knight; also survived by nieces and nephews. No prior visitation. A Celebration of Life Service will be held at the convenience of the family. Memorial contributions may be made to the Cleveland Clinic Lung Transplant Program. Arrangements by: CASTIGLIA FUNERAL HOME, INC., (716) 824-6435, 873 Abbott Rd., South Buffalo, NY 14220. Please share your condolences at: www.castigliafuneralhome.com